Immunosuppression in Xenotransplantation with Wf10
نویسندگان
چکیده
منابع مشابه
Immunosuppression and xenotransplantation of cells for cardiac repair.
The death of highly vulnerable cardiomyocytes during ischemia leads to cardiac dysfunction, including heart failure. Due to limited proliferation of adult mammalian cardiomyocytes, the dead myocardium is replaced by noncontractile fibrotic tissue. Introducing exogenous cells to participate in the regeneration of infarcted myocardium has thus been proposed as a novel therapeutic approach. In vie...
متن کاملA murine model of xenotransplantation of human glioblastoma with immunosuppression by orogastric cyclosporin.
Several animal experimental models have been used in the study of malignant gliomas. The objective of the study was to test the efficacy of a simple, reproducible and low cost animal model, using human cells of glioblastoma multiforme (GBM) xenotransplantated in subcutaneous tissue of Wistar rats, immunosuppressed with cyclosporin given by orogastric administration, controlled by nonimunosuppre...
متن کاملXenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression.
Permselective acrylic membranes were employed to prevent immune rejection of discordant islet xenografts isolated from various large animals. Canine, porcine, and bovine islets were seeded into tubular diffusion chambers and transplanted into the peritoneum of 27 nonimmunosuppressed streptozotocin-induced diabetic Lewis rats. Six recipients received islet grafts from bovine calves, 7 received g...
متن کاملFavorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.
Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow their survival and function without immunosuppression. Here we report successfu...
متن کاملSuccessful hamster-to-rat liver xenotransplantation under FK506 immunosuppression induces unresponsiveness to hamster heart and skin.
In addition to its well-known resistance to antibody (1) and cell-mediated (2) rejection, the liver allograft can confer these advantages to other tissues and organs transplanted concomitantly or subsequently from the donor or donor strain (3, 4). We report here an example of this same hepatic tolerogenicity after hamster livers were transplanted to rats under FK506, ameliorating thereafter the...
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ژورنال
عنوان ژورنال: Pharmacology & Toxicology
سال: 2002
ISSN: 0901-9928
DOI: 10.1034/j.1600-0773.2002.900610.x